A study was made of the effects of physical and release properties of Zaleplon rectal suppositories with a view to providing more information for the optimization of the rectal formulation of Zaleplon. Suppositories were prepared by using water soluble PEG bases. All the prepared suppositories were evaluated for various physical parameters like weight variation, drug content, hardness, melting point, disintegration test. In-vitro release study was performed by using USP type I apparatus using phosphate buffer pH 7.4 as dissolution media. In vitro drug released from water soluble base PEG400:PEG4000 (1:1) was found faster than that from PEG400:PEG6000 (hydrous and anhydrous) bases.
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